When a selectin protein was being carried in a vesicle to its destination, its CRD was initially extending into the post-translational stage.
Inflammation, lymphocyte homing, immune responses, and the homing of bone marrow stem cells are all physiologically dependent on selectins. Atherosclerosis, ischemia-reperfusion injury, inflammatory conditions, and the metastatic development of some tumors are all caused by them.
Selectins are transmembrane proteins that bind carbohydrates and are found on platelets, leukocytes, and endothelial cells (E- and P-selectins). In a variety of clinical circumstances, their function is to mediate the initial steps of the recruitment of leukocytes from the blood stream.
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