Answer:
The excitation-contraction coupling phenomenon was defined by Alexander Sandow, as the sequence of events that occurs from the generation of the action potential in the muscle fiber until the generation of tension begins.
Explanation:
The mechanism of excitation-contraction coupling was defined in skeletal muscle as the sequence of events that occurs from the generation of the action potential in the muscle fiber until the generation of tension begins. The regulation and interaction of these events with each other has been studied during the last 50 years using different techniques, with which the importance and origin of the calcium ion as a contractile activator was established, the main proteins involved are known and the study of the ultrastructural basis and pharmacological regulation; In addition, there is evidence that the excitation-contraction coupling is altered in different situations such as aging, muscle fatigue and some muscle diseases.
