Part A: In Griffith’s experiment, he concluded that some material had been transferred from the heat-killed smooth strain to the rough, nonvirulent strain. Why do you think Griffith chose to call this material the “transforming principle”?

Part B: How did Oswald Avery and his team help to prove that it was DNA, not proteins, which was the “transforming principle” in Griffith’s experiment?

Part A In Griffiths experiment he concluded that some material had been transferred from the heatkilled smooth strain to the rough nonvirulent strain Why do you class=

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Part A : This is because it helped transform the material into DNA, thereby causing the smooth strain transforming into nonvirulent strain.

Part B : They proved it by applying the transformation mechanics, which proved that DNA not the proteins that it is required to transform from smooth strain using DNA.

Hope this helps.

The 'transforming principle' is due to the fact that DNA transferred from non-living cells to living cells could alter the features of living cells. Avery observed it by isolating and transferring the DNA of one bacterium to another.

  • Griffith’s tested different biomolecules and observed that the transforming agent was DNA.

  • This 'transforming principle' could alter the features of living cells when DNA was transferred from non-living cells to living cells.

  • The Avery–MacLeod–McCarty experiment demonstrated that the isolation and transference of the DNA of one bacterium to another could transform the last strain, thereby concluding the genetic material of the cell is DNA instead of protein.

In conclusion, the 'transforming principle' is due to the fact that DNA transferred from non-living cells to living cells could alter the features of living cells. Avery observed it by isolating and transferring the DNA of one bacterium to another.

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