22 - 5(2x + 4)
You want to first open up the parenthesis, by multiplying five by all of the items inside of the parenthesis.
Therefore, it's:
22 - 10x + 20
And then you can move the numbers to simplify it, keeping the symbol before it:
22 + 20 - 10x
And then solve as much as you can:
42 - 10x
And that's how you simplify it.