Sarco/Endoplasmic Reticulum Calcium ATPases (SERCA enzymes) provide an active, ATP-dependent gradient of several thousand-fold calcium ion concentration between the cytosol (low nanomolar) and the ER lumen.
In response to a range of signals, including neurotransmitters and neurotrophic factors, calcium is released from the endoplasmic reticulum (ER) in neurons (Rizzuto 2001). Inositol trisphosphate (IP3) receptors and ryanodine receptors are two separate types of ER calcium channels that mediate calcium release.
A high surface-area-to-volume ratio is the outcome of compartmentalization within a cell.
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