In this case, the negative feedback regulation is not possible not occur. In consequence, the enzyme will be active even when glycolysis is not needed.
Negative feedback happens when a given output is fed back in a way that tends by itself to reduce its fluctuations.
Phosphofructokinase-1 represents the most important enzyme required to carry out glycolysis.
Allosteric regulation refers to the regulatory process by which an enzyme binds an effector molecule at a site different from the active site.
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