The way in which the original comic would be similar to the enlargement is that they have the same proportion.
Based on the fact that when a comic is enlarged, the original and enlargement would remain the same and the only difference would be a larger size.
Hence, we can see that because they have the same proportion, each individual pixel in the original is more visible and the enlargement displays the image in a small number of large pixels.
The use of a grid would likely reduce the effect of pixelation and if there is a reduction in the size of the comic, there would be the same effect, only that it would be smaller, but have the same proportion.
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