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The hyperalgesia that is common in phantom limb pain could potentially be blocked if a new drug was developed that could prevent (without triggering any side-effects) the ______.
a) binding of enkephalins to NMDA receptors
b) diffusion of calcium ions through NMDA receptors
c) release of enkephalins diffusion of enkephalins
d) across synaptic clefts

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Answer: The answer is B- Diffusion of calcium ions through NMDA receptors.

Explanation:

Phantom limb pain (PLP) is a painful sensation experienced after the loss or amputation of a limb. The limb is no longer there but the individual can still feel real and severe pains in the limb. This occurs soon after surgery.

NMDA is a receptor for Glutamate which is an excitatory neurotransmitter. The activation of NMDA receptors are associated with hyperalgesia which is an abnormally heightened sensitivity to pain.

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