Answer:
Option 1 and 2.
Explanation:
Bohr's effect explained the relationship between the binding affinity of oxygen with acidity and carbon dioxide content. Bohr effect was given by the scientist Christian Bohr.
The decrease in pH and increase in the amount of carbon dioxide reducing the binding affinity of oxygen. When the blood travels in tissue from the lungs, pH decreases and oxygen get unload from the hemoglobin as compared with the condition when there is no change in pH.
Thus, the correct answer is option (1)and (2).