The correct answer is: gaps left at the 5' end of the lagging strand
Telomeres are repetitive regions at the very ends of chromosomes found in eukaryotic organisms. The “problem” with telomeres is that the DNA replication cannot be fully finished in each round which result in a slow, gradual shortening of the chromosome.
Gaps at the end of lagging strand are formed because lagging strand is synthesized via Okazaki fragments (small DNA fragments). So, when replication fork during replication reaches the end of the chromosome, a short stretch of DNA does not get covered by an Okazaki fragment and consequently remains uncopied in each round of replication, leaving a single-stranded overhang.
Telomerase is an enzyme that solves this problem by extending the telomeres of chromosomes.
The eukaryotic telomeres replicate differently than the rest of the chromosome as a consequence of gaps left at the 5' end of the lagging strand.
During DNA replication, the leading strand is synthesized as a continuous strand, whereas the lagging strand is synthesized in short fragments known as Okazaki fragments.
Telomeres are repetitive DNA regions localized at the ends of chromosomes.
On the leading strand, DNA is synthesized in a continuous manner until the end of the chromosome is reached.
On the lagging strand, DNA is synthesized in short segments initiated by each RNA primer.
In telomeres, an enzyme called telomerase is responsible for the maintenance of the length of telomeres by adding nucleotides at the 5' end of the lagging strand.
Telomerase contains an RNA sequence that complements the 3' overhang at the end of the chromosome, which is then used to generate the complementary DNA strand.
In conclusion, eukaryotic telomeres replicate differently than the rest of the chromosome as a consequence of gaps left at the 5' end of the lagging strand.
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