Which of the following mutations in the RB gene would be the most likely to contribute to the development of cancer?
a. A mutation that prevents RB from being phosphorylated
b. A mutation that stabilizes RB binding to E2F so that RB no longer releases E2F after being
phosphorylated
c. A mutation that prevents RB from binding to E2F during G1
d. A mutation that causes RB to misfold so that RB is quickly degraded by the cell
e. More than one of these
f. None of these