Which patients are susceptible to developing severe systemic fungal infections? Select all that apply.
1. A patient with cancer who is receiving chemotherapy
2. A patient who is using opioids to manage cancer-related pain
3. A patient who is receiving immunosuppressive agents for lupus
4. A patient who has acquired immune deficiency syndrome (AIDS)
5. A patient who is using thrombolytic agents for myocardial infarction