Which of the following mutations in the RB gene would be the most likely to contribute to the development of cancer?
A.A mutation that prevents RB from being phosphorylated
B.A mutation that stabilizes RB binding to E2F so that RB no longer releases E2F after being phosphorylated
C.A mutation that prevents RB from binding to E2F during G1
D.A mutation that causes RB to misfold so that RB is quickly degraded by the cell
E.More than one of these
F.None of these