Which of the following are true?
I. All enzymes are highly specific for the reactions they catalyze.
II. Prosthetic groups are loosely associated with the polypeptide chain of an enzyme
III. When comparing types of catalysis, the proximity effect provide the largest rate enhancement
IV. Acid-base catalysis involves proton transfers.
A. I, II, III and IV
B. I, III
C. I
D. III
E. IV