Use ___ to prevent relapse of alcohol abuse and dependence and in patients who are actively drinking. ___ is contraindicated in patients receiving or withdrawing from any opioid and in those with liver failure or hepatitis. ___ enhances abstinence but is contraindicated in kidney disease. ___, second-line treatment, leads to the accumulation of acetaldehyde if alcohol is consumed, resulting in flushing, headache, emesis, and the need to avoid all additional alcohol-containing items.