What is a potential problem with using clearance to estimate solute handling, and what is a possible solution?
a) Problem: Clearance does not account for variations in renal blood flow,Solution: Measure renal blood flow separately.
b) Problem: Clearance may be influenced by factors other than glomerular filtration rate, Solution: Use inulin clearance as a more accurate measure.
c) Problem: Clearance is difficult to calculate; Solution: Rely on indirect measures of solute handling.
d) Problem: Clearance is not affected by changes in tubular secretion,Solution: Monitor tubular secretion separately.