The development of atherosclerosis is a process of sequential events. Arrange the pathophysiological events in orders of occurrence.
1. Arterial endothelium injury causes inflammation
2. Macrophages consume low density lipoprotein (LDL), creating foam cells
3. Foam cells release growth factors for smooth muscle cells
4. Smooth muscle grows over fatty streaks creating fibrous plaques
5. Vessel narrowing results in ischemia.