How do the effects of sickle cell disease demonstrate the conformational change in hemoglobin upon releasing oxygen?
a) The sickle-shaped cells result from a change in hemoglobin structure after oxygen release.
b) Sickle cell disease does not involve hemoglobin conformational changes.
c) Hemoglobin remains unchanged in sickle cell disease.
d) The conformational change in hemoglobin is irrelevant to sickle cell disease.