T.P. is a 16-month-old boy (weight 12 kg) admitted to the hospital for a worsening abscess on his right lower inguinal area. The abscess, which appeared 3 days ago, was initially treated at the physician's office with incision and drainage. The area around the abscess is warm and erythematous. The patient has a temperature of 39.2°C, a WBC of 20 × 103 cells/mm3 (46 segs, 15 bands), and a C-reactive protein
(CRP) of 12.8 mg/dL (normal is less than 0.1) The patient has also been receiving oral cephalexin for the past 48 hours. The wound culture from the physician's office is growing MRSA with the following sensitivities. Sensitive: Clindamycin (positive D-test), levofloxacin, linezolid, vancomycin, doxycycline, sulfamethoxazole/trimethoprim. Resistant: Erythromycin, oxacillin, tetracycline.
Which oral antibiotic therapy would you most likely recommend for T.P. on discharge?
a. Clindamycin 150 mg orally every 8 hours.
b. Doxycycline 24 mg orally every 12 hours.
c. Linezolid 120 mg orally twice daily.
d. Sulfamethoxazole/trimethoprim 60 mg orally every 12 hours.