Genetic Advantages and Disadvantages of Sickle-Cell Trait Conduct online research to explore the genetic advantages and disadvantages of the sickle-cell trait. Include the following components in your discussion: Explain the relationship between sickle cell trait, sickle-cell disease, and malaria. Explain the malaria transmission cycle and the role of sickle-cell trait in this cycle. Explain the characteristics of malaria, and its effects on the body. Explore current health initiatives or genetic research regarding sickle-cell trait, malaria, and sickle-cell anemia.