In a first order enzyme-catalyzed reaction, when the concentration of a substrate is much less than the dissociation constant of the enzyme-substrate complex, how does the velocity of the reaction vary with respect to the initial concentration of the substrate.

O As the concentration of the substrate increases, the velocity of the reaction decreases.
O As the concentration of the product increases, the velocity of the reaction increases.
O As the concentration of the substrate increases, the velocity increases.
O As the concentration of the product decreases, the velocity of the reaction increases.