Signal Transduction and the Cytoskeleton

A: Incorrect. Integrins are not located in the nuclear membrane.

B: Correct! Integrins span the plasma membrane and provide a communication link between the extracellular matrix and the cytoskeleton within the cell.

C: Incorrect. Focal adhesions and hemidesmosomes are two kinds of cell matrix junctions, and they are not connected to one another via integrins.

D: Incorrect. These are both components of the cytoskeleton within the cell, and integrins are transmembrane proteins that connect components on opposite sides of a membrane."