In which of the following brain areas would you expect plaques and tangles to appear first in a patient with Alzheimer's disease (What area do they begin in and where do they spread to next)?
- Entorhinal cortex and hippocampus
- Occipital cortex and entorhinal cortex
- Hippocampus and parietal cortex
- Entorhinal cortex and parietal cortex