Select all the correct answers.

Which of these facts were established by other scientists before Charles Darwin published his famous theory of evolution in 1859?
A. Many species have become extinct over time.
B.Variation in characteristics results in the birth of new species.
C.There are many similarities in the anatomy of humans and other species.
D.There are processes in nature that produce organisms that are not able to adapt to the environment.
E.The relationship between evolution and the unity and diversity of life on earth was studied on a large scale.